Sarah F Hamm-Alvarez Selected Research

Dacryocystitis (Dacryoadenitis)

1/2022	Tear miRNAs Identified in a Murine Model of Sjögren's Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism.
10/2021	Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway.
1/2021	Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren's Syndrome.
1/2019	Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide.
1/2017	Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome.
1/2017	Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome.
7/2014	Tear cathepsin S as a candidate biomarker for Sjögren's syndrome.
11/2013	A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome.
10/2010	Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse.
9/2009	Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland.

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Sarah F Hamm-Alvarez Research Topics

Disease

13	Dry Eye Syndromes (Dry Eye Syndrome) 01/2022 - 01/2008
10	Dacryocystitis (Dacryoadenitis) 01/2022 - 09/2009
10	Inflammation (Inflammations) 01/2022 - 11/2013
3	Parkinson Disease (Parkinson's Disease) 01/2020 - 01/2019
3	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 01/2018
2	Infections 03/2020 - 12/2006
2	Rheumatoid Arthritis 12/2018 - 01/2018
1	Hypersensitivity (Allergy) 03/2020
1	Vascular Diseases (Vascular Disease) 01/2020
1	Chronic Obstructive Pulmonary Disease (COPD) 07/2019
1	Disease Progression 01/2019
1	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2018
1	Neoplasms (Cancer) 10/2016
1	Eye Infections 06/2015
1	Wounds and Injuries (Trauma) 12/2014
1	Fever (Fevers) 12/2010
1	Obesity 10/2010
1	Vesicular Stomatitis 08/2008
1	Hyperprolactinemia 04/2007
1	Sjogren's Syndrome (Sjogren Syndrome) 11/2004
1	Hypertension (High Blood Pressure) 04/2002

Drug/Important Bio-Agent (IBA)

4	cathepsin SIBA 01/2022 - 01/2019
4	Sirolimus (Rapamycin)FDA Link 01/2021 - 11/2013
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 10/2010
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2002
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2022 - 12/2018
2	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2020
2	Pharmaceutical PreparationsIBA 01/2021 - 10/2016
2	Therapeutic UsesIBA 01/2021 - 01/2019
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 04/2020 - 01/2019
2	CathepsinsIBA 03/2020 - 10/2010
1	Delayed-Action PreparationsIBA 01/2022
1	Cysteine Proteases (Cysteine Protease)IBA 10/2021
1	Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA 04/2020
1	CystatinsIBA 03/2020
1	Matrix Metalloproteinases (MMPs)IBA 03/2020
1	Metalloproteases (Metalloproteinases)IBA 03/2020
1	Peptide Hydrolases (Proteases)FDA Link 03/2020
1	Plasminogen Activators (Plasminogen Activator)IBA 03/2020
1	Protease Inhibitors (Protease Inhibitor)IBA 03/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	RibonucleoproteinsIBA 01/2020
1	SynucleinsIBA 12/2019
1	Peptides (Polypeptides)IBA 01/2019
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2018
1	MacrolidesIBA 12/2018
1	Secretory Immunoglobulin A (SIgA)IBA 01/2018
1	Ophthalmic Solutions (Eye Drops)IBA 01/2017
1	InterferonsIBA 01/2017
1	Aquaporin 5IBA 01/2017
1	PolymersIBA 11/2013
1	Carrier Proteins (Binding Protein)IBA 11/2013
1	Zinc Oxide FDA Link 12/2010
1	MetalsIBA 12/2010
1	CytokinesIBA 10/2010
1	LipidsIBA 09/2009
1	Glycoproteins (Glycoprotein)IBA 08/2008
1	Capsid Proteins (Capsid Protein)IBA 12/2006
1	IntegrinsIBA 12/2006
1	adenovirus receptorIBA 12/2006
1	ClathrinIBA 12/2006
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 11/2004
1	Sodium-Hydrogen ExchangersIBA 04/2002

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2008
2	Refractive Surgical Procedures 03/2020 - 12/2014
1	Contact Lenses 03/2020
1	Topical Administration 01/2019